Laboratory Tested Solvent
This product is intended for use as a mild solvent only. The choice of the process used in the various applications is the sole responsibility of the user. Please consult with your veterinarian as to the proper use of DMSO.
DMSO (dimethyl sulfoxide) Gel is recommended as a topical application to reduce acute swelling due to trauma.
Off-Label Administration and Dosage:
Recommended as a topical application to reduce swelling due to trauma.
CONSULT YOUR PHYSICIAN OR VETERINARIAN BEFORE USING THIS PRODUCT ON A PERSON OR ANIMAL. Any use other than as a solvent is considered off-label use.
DMSO Gel is to be administered topically to the skin over the affected area.
Dogs - Liberal application should be administered three to four times daily. Total daily dosage should not exceed 20 g. Total duration of therapy should not exceed 14 days.
Horses - Liberal application should be administered two to three times daily. Total daily dosage should not exceed 100 g. Total duration of therapy should not exceed 30 days.
Basic Medical Properties: DMSO is recommended as a topical application to reduce acute swelling due to trauma.
DMSO is a rapidly absorbed skin penetrant. With the ability to carry other substances through membranes it acts as an anti-inflammatory agent. DMSO is also a cryoprotective agent that helps protect frozen tissue. Additionally, DMSO is a potent antioxidant, scavenging the highly reactive molecules that contribute to disease and aging, known as free radicals.
It has been found that medications dissolved in DMSO retain their therapeutic activity and their specific properties over a longer period of time. It maintains and multiplies the activity of many drugs. Allergic reactions are diminished by the actions of DMSO.
Side Effects:
In general, adverse reactions are local, and while they may prove to be annoying to some patients, they are usually not of a serious nature. Upon topical application, an occasionally animal may develop transient erythema, associated with local burning or smarting. Even when erythema or vesiculation occurs, they are self-limiting reversible states, and not necessarily an indication to discontinue medication. Dryness of the skin and an oyster-like breath odor have been reported. These effects are temporary and are not considered to be of serious consequence. Changes in the refractive index of the lens of the eye and nuclear cataracts have been observed in animals, with the use of this drug. This appears to be related to dosage and duration of therapy.
Precaution and Contraindications:
Contact between DMSO Gel and the skin should be avoided. Rubber gloves should be worn while applying this drug. Forceps and swabs may be used to facilitate application. If absorbed through the skin, DMSO Gel will cause odorous breath and unpleasant mouth taste. Mild sedation or drowsiness, sensations of warmth, burning, irritation, itching and mild erythematous localized or generalized dermatitis have been reported in some persons following exposure to DMSO Gel. Treatment of such side effects is symptomatic. Consult a physician immediately if adverse effects appear.
DMSO Gel may mask certain disease signs such as seen in fractures, etc.; this does not obviate the need for specific therapy in such conditions.
Since DMSO Gel effectively alters the biologic membrane, it will in some cases facilitate the systemic absorption of other topically applied drugs and may have a potentiating effect on drugs administered systemically.
DMSO Gel should be judiciously used when administered in conjunction with other pharmaceutical preparations, especially those affecting the cardiovascular and central nervous systems.
DMSO Gel may enhance the absorption of other materials into the skin. The veterinarian should make certain that other medications are not present prior to its application.
Keep DMSO Gel out of the reach of children.
DMSO Gel is recommended for topical application only. DO NOT ADMINISTER BY ANY OTHER ROUTE.
DMSO Gel should not be used under occlusive dressings.
DMSO Gel is contraindicated in horses and dogs intended for breeding purposes.
DMSO Gel is a potent solvent and may have a deleterious effect on fabrics, plastics and other materials. Care should be taken to prevent physical contact with DMSO Gel.
DMSO Gel should not be administered to horses that are to be slaughtered for food.
CAUTION: HYGROSCOPIC. CLOSE CAP TIGHTLY AFTER USE. AVOID FREEZING. DUE TO THE RAPID PENETRATION ABILITY OF DMSO GEL, RUBBER GLOVES SHOULD BE WORN WHEN APPLYING THIS PRODUCT.
