NOTE: Regular determinations of prothrombin time response should be performed to guide in the initial and subsequent administration of Vitamin K1 Chewable Tablets. The dosage should be adjusted accordingly.
CONTRAINDICATION: Hypersensitivity to any component of this medication.
ACTIONS: Vitamin K1 Chewable Tablets for oral administration possess the same type and degree of activity as does naturally occurring Vitamin K. The primary function of Vitamin K is to stimulate the production via the liver of active prothrombin from a precursor protein. The mechanism by which Vitamin K promotes formation of prothrombin at the molecular level has not been established.
DESCRIPTION: Vitamin K1 Chewable Tablets contain phytonadione with excipients in a beef-flavored tablet.
DOSAGE AND ADMINISTRATION: Dogs and Cats
Hypoprothrombinemia (with hemorrhage) - Administer orally at the rate of 2.5-5 mg/kg of body weight (1 tablet per each 22 pounds of body weight for lower dosage or 1 tablet per each 11 pounds of body weight for higher dosage) daily as conditions require up to 3 weeks. Frequency and amount of oral administration should be guided by regular determination of prothrombin time. The smallest effective dose should be sought to minimize the risk of adverse reactions.
WARNINGS: It is recommended that Vitamin K1 Chewable Tablets be used in follow-up therapy only after administration of Vitamin K1 Injection and hospitalization is no longer required. An immediate coagulant effect should not be expected after administration of phytonadione when administered orally. Phytonadione will not counteract the anticoagulant action of heparin. Repeated large doses of Vitamin K1 are not warranted in hepatic disease if the response to the initial therapy is unsatisfactory. Failure to respond to Vitamin K1 may indicate that the condition being treated is inherently unresponsive to Vitamin K1.
PRECAUTIONS: Patient may develop temporary resistance to prothrombin-depressing anticoagulants, especially when given larger doses of phytonadione.
CAUTION: Vitamin K1 Chewable Tablets are sold only to licensed veterinarians.
STORAGE AND HANDLING: Protect product from light at all times. Keep out of reach of children. Store at room temperature.
Supplied as Vitamin K1 Chewable Tablets are available in bottles of 50 Chewable Tablets.
